3. Go for combos

The two best combinations are the wrapped candy and the striped candy, and the sprinkle donut hole and the striped candy. Together, they can wipe out over half the board for you. This can also help you get to places which are off the board or otherwise difficult to reach. This is the only way you will get by levels such as 181, which have unreachable squares. Also, a wrapped candy switched with another wrapped candy will ignite a 6 by 4 square which can clear a huge area.